Ipratropium Bromide, also known as Bromide of Isopropyl Atropine, is an important bronchodilator primarily used in the treatment of respiratory diseases.
I. Basic Information
English Name: Ipratropium Bromide
Chemical Formula: There are multiple possible chemical formulas, such as C20H30BrNO3 or C20H32BrNO4, which may be due to different forms or salts.
Molecular Weight: The molecular weight varies depending on the chemical formula. For example, the molecular weight of C20H30BrNO3 is 412.36.
II. Pharmacological Action
Ipratropium Bromide is a potent anticholinergic drug with high selectivity for the M-receptors in bronchial smooth muscles. Its main mechanism of action is to antagonize the acetylcholine neurotransmitter released by the vagus nerve, thereby inhibiting vagus nerve reflexes, relaxing bronchial smooth muscles, alleviating bronchial spasms, and achieving a bronchodilatory effect. Additionally, Ipratropium Bromide has relatively weak effects on respiratory gland secretion and the cardiovascular system. The dose required for bronchodilation is much lower than that needed to inhibit gland secretion or increase heart rate.
III. Indications
Chronic Obstructive Pulmonary Disease (COPD): Ipratropium Bromide is used to treat bronchial spasms, wheezing, and other symptoms caused by COPD, helping to improve patients' quality of life.
Prevention and Treatment of Asthma: For asthma patients, especially those who cannot tolerate β-adrenoceptor agonists due to muscle tremors, tachycardia, or other side effects, Ipratropium Bromide provides an effective treatment option.
