Basic Information

• CAS Number: 127-07-1

• Product Name: Hydroxyurea

• Other Names: N-Hydroxyurea, Hydroxy Urea, etc.

• Molecular Formula: CH4N2O2

• Molecular Weight: 76.06 g/mol

Physical Properties

• Appearance: White to pale yellow powder

• Density: Approximately 1.5±0.1 g/cm3

• Melting Point: Ranges from 135-140°C or 141-146°C (with decomposition)

• Boiling Point: 222.1±23.0°C at 760 mmHg

• Flash Point: 88.1±22.6°C

• Refractive Index: 1.543

• Vapor Pressure: 0.0±1.0 mmHg at 25°C

• Solubility: Highly soluble in water and hot ethanol; slightly soluble in cold ethanol; insoluble in ether and benzene.

Chemical Properties

• Stability: It is unstable when exposed to water or heat.

• pH: Not specifically mentioned, but it is a chemical compound and its pH in solution may vary depending on the conditions.

• Reactivity: It may react with certain chemicals, especially under conditions that promote decomposition or hydrolysis.

Biological and Pharmacological Properties

• Mechanism of Action: Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis by inhibiting ribonucleotide diphosphate reductase. It acts primarily on the G1 and S phases of proliferating cells, delaying the G1/S interface.

• Medical Applications: It is used in the treatment of chronic myelogenous leukemia (CML) and may also be used in the treatment of metastatic ovarian cancer, primary squamous cell carcinoma of the head and neck, and psoriasis.

• Toxicity: It should be handled with care as it may have toxic effects if not used properly.