Specific Rotation: D25 -6.81° (c = 0.665 in 0.1 M HCl)
Solubility: Soluble in water (oxygen-free), with a solubility range of 19.60 - 20.40 mg/mL. The solution is clear to slightly hazy and colorless to faintly yellow.
Stability: Hygroscopic
Density: Approximately 1.9±0.1 g/cm3
Boiling Point: 506.6°C at 760 mmHg
Flash Point: 260.2°C
Refractive Index: 1.822
Chemical Properties
pH Adjustment: It can be prepared by adjusting the pH of a mixed aqueous solution containing biopterin using triethylamine.
Synthesis: Involves hydrogenation and acidification processes to obtain the final product.
Biochemical and Pharmacological Properties
Biological Role: Sapropterin Hydrochloride is a synthetic dihydrochloride salt of tetrahydrobiopterin (BH4). It serves as an activator of phenylalanine hydroxylase (PAH), tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthase.
Mechanism of Action: As a cofactor for these enzymes, it participates in the synthesis of neurotransmitters and other biologically active compounds.
Medical Applications: It is used in the treatment of phenylketonuria (PKU) and other conditions where BH4 deficiency is implicated.
Storage Conditions: It should be stored at -20°C to maintain its stability.
