Appearance: Yellowish-white to pale yellow powder or loose block
Boiling Point: 265.6°C at 760 mmHg (for reference only, as the boiling point of Nedaplatin may vary under different conditions)
Solubility: Good water solubility
Chemical Properties
Derivative: Nedaplatin is a derivative of cisplatin, displaying antineoplastic and antitumor effects in vitro.
DNA Damage: It causes DNA damage to tumor colony-forming units, with an IC50 value of 94 μM.
Stability: It should be stored under appropriate conditions to maintain its stability and efficacy.
Pharmaceutical Properties
Category: Antineoplastic agent, Platinum-based antitumor drug (third-generation after cisplatin and carboplatin)
Mechanism of Action: It inhibits DNA synthesis and has antitumor activity.
Indications: It is used for the treatment of solid tumors such as head and neck cancer, small cell lung cancer, non-small cell lung cancer, esophageal cancer, ovarian cancer, and cervical cancer.
Dosage and Administration: It is administered intravenously after being dissolved in saline and diluted to 500 ml. The infusion time should not be less than 1 hour, followed by continued infusion of more than 1000 ml of fluid. The recommended dose is 80-100 mg/m² per administration, with one dose per course of treatment and an interval of 3-4 weeks before the next course.
