Storage Conditions: 2-8°C (Some sources recommend -20°C for long-term storage)
Solubility: Sparingly soluble in water, slightly soluble in methanol, and practically insoluble in acetone. Soluble to 5 mM in water and to 75 mM in DMSO.
Chemical Properties
Type: Organic compound, specifically an antineoplastic agent.
Mechanism of Action: Mitoxantrone hydrochloride intercalates into DNA, stabilizing the cleavable complex of topoisomerase II and DNA, which increases the incidence of double-strand breaks and inhibits DNA synthesis. It also exhibits immunosuppressive activity by inhibiting the proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells.
Pharmacological Properties
Indications: Primarily used in the treatment of malignant lymphomas, breast cancer, and acute leukemia. It also has certain efficacy in the treatment of lung cancer, melanoma, soft tissue sarcomas, multiple myeloma, liver cancer, colorectal cancer, renal cancer, prostate cancer, endometrial cancer, testicular tumors, ovarian cancer, and head and neck cancer.
Dosage and Administration: Administered intravenously as a solution in sodium chloride or 5% glucose injection. The dosage varies based on body surface area and is typically administered every 3-4 weeks or daily for 3-5 days with a 2-3 week interval between cycles.
