Health Insurance Coverage: Omeprazole Sodium Enteric-coated Tablets are covered under Category A of the medical insurance system. Injectable Esomeprazole Sodium and Injectable Omeprazole Sodium are covered under Category B.
Indications:
Omeprazole Sodium is primarily used to treat various digestive system disorders, including:
Peptic ulcers (gastric and duodenal ulcers)
Reflux esophagitis
Zollinger-Ellison syndrome (gastrinoma)
It can also be used for the prevention of bleeding from peptic ulcer, anastomotic ulcer, acute gastric mucosal injury under stress conditions, and acute gastric mucosal injury caused by non-steroidal anti-inflammatory drugs.
Prevention of upper gastrointestinal bleeding caused by severe diseases (such as cerebral hemorrhage, severe trauma, etc.) and after gastric surgery.
Adverse Reactions:
Omeprazole Sodium is generally well-tolerated, with most adverse reactions being mild and reversible. Common adverse reactions include:
Headache, diarrhea, nausea, abdominal pain, flatulence, and constipation
Occasional elevation of serum aminotransferases (ALT, AST), rash, dizziness, drowsiness, insomnia, etc.
Rarely, reversible mental confusion, agitation, aggressive behavior, depression, hallucinations (more common in severe cases), elevated liver enzymes, hepatitis, photosensitivity, polymorphic erythema, etc.
Precautions:
Omeprazole Sodium is contraindicated in patients with known hypersensitivity to omeprazole, esomeprazole, other benzimidazole compounds, or any other component of the product.
The concurrent use of Omeprazole Sodium with nelfinavir is contraindicated, and its use with atazanavir is not recommended.
The use of PPIs may slightly increase the risk of gastrointestinal infections, such as Salmonella and Campylobacter.
Long-term use may lead to decreased vitamin B12 stores or reduced vitamin B12 absorption, which should be considered.
Drug Interactions:
Omeprazole Sodium is a CYP2C19 inhibitor, and potential interactions with other drugs metabolized by CYP2C19 should be considered when starting or stopping treatment with Omeprazole Sodium. Specifically, concurrent use of Omeprazole Sodium with clopidogrel is not recommended.
Storage and Shelf Life:
Storage: Omeprazole Sodium should be stored in a tightly closed container, protected from light, and kept in a cool place. The specific storage requirements may vary depending on the formulation.
