Vonoprazan Fumarate (TAK-438) is a novel oral anti-gastric acid medication jointly developed by Takeda Pharmaceutical Company and Otsuka Pharmaceutical Co., Ltd. Here is a detailed introduction to this medication:
Basic Information
Chinese Name: 富马酸沃诺拉赞
English Name: Vonoprazan Fumarate
Chemical Formula: C21H20FN3O6S
Molecular Weight: 461.4634032
CAS Registry Number: 1260141-27-2
EINECS Number: 250-635-4
Drug Classification and Mechanism of Action
Classification: Proton Pump Inhibitor (PPI)
Mechanism of Action: As a potent and orally active potassium-competitive acid blocker (P-CAB), Vonoprazan Fumarate exhibits antisecretory activity. It inhibits the H+, K+-ATPase enzyme activity in gastric parietal cells, thereby reducing gastric acid secretion.
Clinical Applications
Indications: Developed for the study of acid-related diseases such as Gastroesophageal Reflux Disease (GERD) and Peptic Ulcer Disease (PUD).
Side Effects and Precautions
Common Side Effects: Include headache, nausea, abdominal pain, diarrhea, and increased cholesterol levels. While most side effects are usually mild and temporary, some patients may experience severe allergic reactions or other serious side effects.
Precautions:
Use with caution in patients with impaired liver or kidney function, and regular monitoring is required.
Follow medical advice and do not adjust the dosage without instruction.
Seek medical attention promptly if discomfort occurs.
Regular endoscopic examinations are necessary for close observation during long-term use.
Use with caution in pregnant and lactating women, as adequate clinical studies have not been conducted in these populations.
Drug Interactions
As a PPI, Vonoprazan Fumarate may affect the metabolism of other drugs, particularly those metabolized by the CYP2C19 enzyme. Therefore, attention should be paid to potential drug interactions when using this medication.
Additional Information
Storage Conditions: Store in a cool, dry place, protected from direct sunlight.
In summary, Vonoprazan Fumarate is a novel and highly effective anti-gastric acid medication suitable for the treatment of various acid-related diseases. However, it is essential to be aware of its side effects, precautions, and drug interactions to ensure safe and effective medication use.
