I. Basic Information

• Product Name: Osimertinib Mesylate

• CAS Number: 1421373-66-1

• Brand: MedChemExpress (MCE), among others

II. Chemical Properties

• Molecular Formula: The specific molecular formula may vary depending on product specifications and manufacturing processes, but typically includes a mesylate group and the parent structure of osimertinib.

• Molecular Weight: Similarly, it may differ based on product specifications and manufacturing processes.

• Appearance: Generally appears as a white or nearly white powder.

• Solubility: Soluble in appropriate solvents, with specific solubility varying depending on solvent type and concentration.

III. Pharmaceutical Characteristics

• Category: An orally active, third-generation EGFR (Epidermal Growth Factor Receptor) tyrosine kinase inhibitor (TKI).

• Mechanism of Action: Irreversibly inhibits EGFR mutants, particularly the EGFR T790M mutant, thereby blocking signaling pathways and inhibiting tumor growth.

• Biological Activity: Demonstrates an apparent IC50 value of 12 nM against EGFR mutants with the L858R mutation and 1 nM against EGFR mutants with both the L858R and T790M mutations.