Molecular Weight: 488.00600 (alternatively, 488.01 or 488.005, due to slight variations in measurement or calculation methods)
II. Physical Properties
Appearance and Characteristics: Grayish-white to yellow solid
Density: 1.408g/cm³ (alternatively, 1.4±0.1g/cm³, depending on measurement conditions or methods)
Melting Point: 275~286°C
III. Chemical Properties
Type: An orally active, ATP-competitive, dual Src/Bcr-Abl inhibitor with potent antitumor activity
Inhibitory Activity: Ki values for Src and Bcr-Abl are 16pM and 30pM, respectively; IC50 values for inhibiting Bcr-Abl and Src are <1.0 nM and 0.5 nM, respectively
Other Inhibitory Activities: Also exhibits significant activity against multiple kinases such as c-KIT, ephrin (EPH) receptor kinases, and PDGFβ receptor, and induces apoptosis and autophagy
