Boiling Point: 764ºC (or 764.0±70.0°C at 760 mmHg)
Flash Point: 415.8ºC (or 415.8±35.7°C)
Physical State and Solubility
Appearance: Zoledronic acid typically exists as a white to off-white crystalline powder or solid powder.
Solubility: Zoledronic acid has a certain solubility in water, with specific solubility varying depending on the preparation process and conditions. It has been reported to be soluble in water up to 25mM.
Stability and Storage Conditions
Stability: Zoledronic acid is a relatively stable compound with long-term stability under common storage conditions.
Storage Conditions: Zoledronic acid should be stored in a dry, cool place away from sunlight and moisture to prevent decomposition or loss of potency. It has been recommended to store at -20°C with a shelf life of up to 2 years. Once dissolved in a solvent, it should be used within one month at -20°C if possible.
Pharmaceutical Forms and Uses
Pharmaceutical Forms: Common pharmaceutical forms of zoledronic acid include injectable solutions and oral tablets. Injectable solutions are used for intravenous administration, while oral tablets are used for longer-term treatment and prevention.
Uses: Zoledronic acid is a potent bisphosphonate drug primarily used for the treatment of bone pain caused by osteolytic bone metastases of malignant tumors and osteoporosis. It also inhibits osteoclast-mediated bone resorption and has antitumor activity. Additionally, zoledronic acid is used to treat hypercalcemia of malignancy and can help alleviate pain caused by bone metastases.
