Basic Information

• Product Name: Azacitidine

• CAS Number: 320-67-2

• Molecular Formula: C8H12N4O5

• Molecular Weight: 244.205

Physical Properties

• Appearance: White or off-white crystalline powder

• Density: 2.1±0.1 g/cm3

• Boiling Point: 534.5±60.0 °C at 760 mmHg

• Melting Point: 226-232 °C (dec.)

• Flash Point: 277.0±32.9 °C

• Refractive Index: 1.823

• Vapor Pressure: 0.0±3.2 mmHg at 25°C

• Solubility: Soluble in DMSO (e.g., 50 mg/mL with shaking or ultrasonic assistance), slightly soluble in water (e.g., 10 mg/mL or 20 mg/mL), also soluble in acetic acid-water solution (1:1 v/v, solubility of 5 mg/mL) and tissue culture media (1.2 mg/10 mL).

Chemical Properties

• Stability: Relatively stable under certain conditions but may decompose at high temperatures, strong acids, or strong bases.

• Mechanism of Action: As a cytosine analog, it is a DNA methyltransferase inhibitor (DNMT inhibitor) that can embed into DNA/RNA and inhibit DNA methyltransferase activity, leading to the depletion of DNMT activity in cells and DNA demethylation.