Alternative Names: 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxaphosphinane 2-oxide, NSC 109724, Isophosphamide
CAS Number: 3778-73-2
Molecular Formula: C7H15Cl2N2O2P
Molecular Weight: 261.086
Physical Properties
Appearance: Crystalline solid
Density: 1.3±0.1 g/cm³
Boiling Point: 336.1±52.0 °C at 760 mmHg
Melting Point: 48ºC
Flash Point: 157.1±30.7 °C
Vapor Pressure: 0.0±0.7 mmHg at 25°C
Refractive Index: 1.506
Solubility: Soluble in water, easily soluble in ethanol, acetone, chloroform, and methanol
Chemical Properties
Category: Alkylating agent (DNA alkylator), with broad-spectrum antitumor activity
Mechanism of Action: Ifosfamide is an alkylating chemotherapeutic agent that alkylates and forms DNA cross-links, thereby preventing DNA strand separation and DNA replication, and inhibiting the growth and division of tumor cells.
Activation: Ifosfamide is a prodrug that must be activated by hydroxylation via hepatic microsomal enzymes.
