Basic Information

• Product Name: Irinotecan Hydrochloride

• CAS Number: 100286-90-6 

• Molecular Formula: Primarily C33H38N4O6·HCl, with variants such as C33H45ClN4O9 (e.g., trihydrate)

• Molecular Weight: 623.14 (for C33H38N4O6·HCl form), 677.192 (for C33H45ClN4O9 form)

Physical Properties

• Appearance: Yellow powder or pale yellow to yellow crystalline powder

• Melting Point: 250~256°C (dec.)

• Boiling Point: 257°C (under certain conditions)

• Flash Point: 482°C

• Solubility: Soluble in DMSO or DMF at concentrations of approximately 20 mg/ml; slightly soluble in aqueous buffers; practically insoluble in acetone; some sources indicate slight solubility in ethanol and chloroform

• Stability: Stable under normal temperature and pressure; avoid contact with strong oxidants

Chemical Properties

• Category: A topoisomerase I inhibitor and a camptothecin derivative

• Mechanism of Action: Metabolized in vivo to the active metabolite SN-38, which binds to topoisomerase I, leading to DNA single-strand breaks and double-strand breaks, thereby inhibiting DNA replication and transcription and triggering apoptosis