Ramosetron Hydrochloride, also known as Ramosetron HCl, is a crucial pharmaceutical compound primarily used for the prevention and treatment of nausea and vomiting, particularly those caused by antineoplastic (anti-cancer) drug therapy.
Basic Information
CAS Number: 132907-72-3
English Name: Ramosetron Hydrochloride
Chinese Name: 盐酸雷莫司琼
Molecular Formula: C17H18ClN3O (Note: Some sources may indicate C17H17N3O·HCl, accounting for the presence of the hydrochloride salt)
Molecular Weight: 315.8 (depending on the formula representation)
Physical Properties
Melting Point: 244-246°C
Appearance: White to off-white powder
Solubility: Soluble in water, yielding a clear solution at 20 mg/mL
Optical Rotation: [α]/D -40 to -45°, c = 1 in methanol
Storage Conditions
Storage Temperature: Recommended to be stored at -20°C or below, though some sources suggest a range of -25°C to -15°C. Room temperature storage is also feasible, but dryness is essential.
Storage Method: Keep in a dark and dry place, avoiding repeated freeze-thaw cycles.
Pharmacological Effects
Mechanism of Action: Ramosetron Hydrochloride is a selective 5-HT3 receptor antagonist with potent antiemetic properties. It inhibits nausea and vomiting by blocking the 5-HT3 receptor, which is activated by agents such as cisplatin during anticancer therapy.
Experimental Evidence: In guinea pig isolated colon contraction experiments induced by serotonin and in rats and ferrets, it has demonstrated antagonism of the 5-HT3 receptor, as evidenced by inhibition of Bezold-Jarisch reflexes.
Uses
Primary Use: For the management of nausea and vomiting associated with antineoplastic drug therapy.
Research Use: Also utilized in research fields such as pharmacology and pharmacokinetics.
Precautions
Follow relevant laboratory safety protocols and wear appropriate protective gear when handling Ramosetron Hydrochloride.
Centrifuge the powder briefly before dissolution to ensure it is at the bottom of the vial.
Store the powder away from light and moisture, avoiding repeated freeze-thaw cycles.
Do not inhale, ingest, or allow direct contact with skin or eyes.
This product is intended for research use only and must not be administered to humans.
Supplier Information
Multiple suppliers worldwide offer Ramosetron Hydrochloride, including but not limited to Qingdao Jieshikang Biotechnology Co., Ltd. and Yesen Biotechnology (Shanghai) Co., Ltd.
Prices, specifications, and packaging may vary among suppliers. Contact the supplier directly for specific information.
This translation provides a comprehensive overview of Ramosetron Hydrochloride, including its basic information, physical properties, storage conditions, pharmacological effects, uses, precautions, and supplier information.
