Gabexate mesylate, also known as Gabexate Mesilate, is a non-antigenic serine protease inhibitor that mimics trypsin. Here is a more detailed translation into English:

Basic Information

• English Name: Gabexate Mesylate

• Chinese Name: 甲磺酸加贝酯

• CAS Number: 56974-61-9

• Chemical Formula: C17H27N3O7S

• Molecular Weight: 417.477

• Appearance: White crystalline solid

Physical Properties

• Density: Not provided

• Boiling Point: 508.6ºC at 760 mmHg

• Melting Point: Not provided

• Flash Point: 261.4ºC

Uses and Pharmacological Effects

• Uses: Gabexate Mesylate is primarily used for research purposes and is strictly prohibited for clinical medical use or other applications. However, in the pharmaceutical industry, its analogues or formulations (such as Gabexate Mesilate for Injection) can be used in the treatment of acute mild (edematous) pancreatitis and as an adjunctive therapy in acute necrotizing pancreatitis.

• Pharmacological Effects: As a non-peptide protease inhibitor, Gabexate Mesylate inhibits the activity of various proteases such as trypsin, kallikrein, fibrinolysin, and thrombin, thereby suppressing the pathological changes caused by these enzymes. In experimental models of acute pancreatitis in animals, it has been shown to inhibit activated trypsin, reduce pancreatic injury, and improve elevated levels of serum amylase, lipase activity, and urea nitrogen.

Storage Conditions

• Gabexate Mesylate should be stored in a cool, dry place with good ventilation or exhaust equipment. The specific storage conditions may vary depending on the product form (e.g., raw material, formulation). For research use, it is generally recommended to store at -20°C with a shelf life of 2 years. After dissolution in a solvent, it is advisable to use within one month while stored at -20°C.

Precautions

• When handling Gabexate Mesylate, wear appropriate protective gear such as lab coats, gloves, and safety glasses to avoid direct contact with skin or eyes.

• In case of accidental inhalation, skin contact, or eye contact, take immediate appropriate first aid measures, such as moving to fresh air, washing the skin or eyes with soap and plenty of water.

• The use of Gabexate Mesylate and its analogues in medical applications should strictly follow the guidance of a physician, and attention should be paid to potential adverse reactions and contraindications.

Conclusion

Gabexate Mesylate, as a non-antigenic serine protease inhibitor mimicking trypsin, holds potential application value in research. However, in medical applications, its use should strictly adhere to physician's instructions, with attention to relevant precautions and contraindications.