Appearance: White or nearly white powder, odorless, and highly hygroscopic.
Melting Point: Ranges from 183-185°C (dec.) or 300°C (as reported in different sources).
Boiling Point: 793°C or 707.1°C at a specific pressure.
Refractive Index: 180° (C=0.8, H2O).
Solubility: Soluble in water, methanol, and ethanol. Insoluble in acetone and other organic solvents.
Stability: Stable under normal conditions but should be stored in an inert atmosphere at 2-8°C to maintain optimal quality.
III. Pharmaceutical Properties
Antibacterial Spectrum: Piperacillin sodium salt is a semi-synthetic penicillin antibiotic with a broad spectrum of antibacterial activity. It is effective against both Gram-positive and Gram-negative bacteria, including Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter species, and many anaerobic bacteria.
Mechanism of Action: Piperacillin sodium salt inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) located in the bacterial cell wall. This binding disrupts the final stages of cell wall synthesis, leading to bacterial cell lysis and death.
Indications: Clinically, it is used to treat infections caused by susceptible bacteria, such as sepsis, urinary tract infections, respiratory infections, biliary tract infections, abdominal infections, pelvic infections, and skin and soft tissue infections.
