Appearance: Soft, colorless powder or white to creamy-white crystals
Density: 1.2±0.1 g/cm3
Melting Point: 138~140ºC
Boiling Point: 818.4±65.0 °C at 760 mmHg
Flash Point: 448.8±34.3 °C
Refractive Index: 1.535
Solubility: Practically insoluble in water but freely soluble in acetone, alcohol, chloroform, and also soluble in 1,2-dichloroethane, ether
III. Chemical Properties
Erythromycin belongs to the macrolide class of antibiotics, produced by Streptomyces erythreus.
Erythromycin reversibly binds to the bacterial 50S ribosome, inhibiting protein synthesis and thereby exerting its antibacterial effect.
IV. Pharmaceutical Properties
Indications: Clinically used primarily for the treatment of Staphylococcus infections resistant to penicillin and related conditions.
Contraindications: Caution should be exercised in patients with hepatic insufficiency and during pregnancy.
Drug Interactions: Erythromycin may interact with other medications. Consult your doctor or pharmacist if you need to use other medications simultaneously.
Dosage Forms: Common dosage forms of erythromycin include granules, tablets, and capsules, allowing patients to choose the appropriate route of administration based on their needs.
