Product Name: Amikacin Disulfate (also commonly written as Amikacin Sulfate)
CAS Number: 39831-55-5
Molecular Formula: Various representations exist, such as C22H45N5O17S (simplified form, not considering the hydration state of the sulfate radical), or C22H47N5O21S2 (considering the sulfate radical in its dihydrate form), etc.
Molecular Weight: Likewise, it varies depending on the molecular formula representation, such as 683.68 (simplified form) or 781.76 (dihydrate form), etc.
II. Physical Properties
Appearance: White to off-white powder
Melting Point: 220°C to 230°C
Solubility: Soluble in water, with solubility affected by temperature; heating can increase solubility; insoluble in organic solvents such as acetone
pH Value: In aqueous solution (10g/L, 25°C), the pH ranges from 2.0 to 4.0
III. Chemical Properties
Stability: It has a certain degree of hygroscopicity and should be stored in a dry, cool place
Mechanism of Action: As an aminoglycoside antibiotic, it directly acts on the 30S and 50S ribosomal subunits of bacteria, inhibiting protein synthesis and thereby exerting bactericidal effects
IV. Pharmaceutical Characteristics
Antibacterial Spectrum: It is effective against most Gram-negative bacteria, including strains resistant to gentamicin and tobramycin; it also inhibits infections caused by susceptible Nocardia and nontuberculous mycobacteria
Uses: Primarily used to treat urinary tract infections, sepsis, skin infections, bone and joint infections, pneumonia, and lower respiratory tract infections caused by sensitive bacteria
