Appearance: Fosfomycin Trometamol appears as a white or almost white crystalline powder.
Solubility: It is extremely soluble in water, soluble in methanol, slightly soluble in ethanol, and insoluble in chloroform.
Melting Point: 122-125°C
Stability: It is hygroscopic and should be stored in a dry place.
Chemical Properties
Fosfomycin Trometamol is a mixture of fosfomycin and trometamol (2-amino-2-hydroxymethyl-1,3-propanediol) in a 1:1 ratio, with fosfomycin being the active ingredient.
The fosfomycin molecule is structurally similar to phosphoenolpyruvate and binds irreversibly to the pyruvate-uridine diphosphate-N-acetylglucosamine transferase, interfering with the first step of bacterial cell wall peptidoglycan synthesis and inhibiting subsequent reactions, thereby exerting a bactericidal effect.
Pharmacological Effects
Fosfomycin Trometamol is a broad-spectrum bactericidal antibiotic that exerts its antibacterial effect by inhibiting bacterial cell wall synthesis.
It inhibits both Gram-positive and Gram-negative bacteria, with a spectrum of activity including Escherichia coli, Shigella, Proteus, Serratia, Staphylococcus aureus, and Pseudomonas aeruginosa.
