Appearance: White or off-white crystalline powder.
Odor: Odorless (some sources indicate a slight taste of bitterness).
Solubility: Practically insoluble in water; soluble in ethanol or acetone; more soluble in methanol or ether.
Density: 1.25 g/cm³
Melting Point: 115-120 ºC
Boiling Point: 864.7 ºC
Pharmaceutical Properties
Antibiotic Class: Roxithromycin belongs to the new generation of macrolide antibiotics.
Mechanism of Action: It binds to the 50S ribosomal subunit of bacteria, blocking peptide transfer and mRNA shifting, thereby inhibiting bacterial protein synthesis.
Antibacterial Spectrum: It is mainly effective against Gram-positive bacteria, anaerobes, Chlamydia, and Mycoplasma. Its in vitro antibacterial activity is similar to that of erythromycin, but its in vivo antibacterial activity is 1 to 4 times stronger.
Indications: It is used for respiratory tract infections, urinary tract infections, skin and soft tissue infections, such as bronchitis, pneumonia, pyelonephritis, cystitis, otolaryngological infections, enteritis, and dysentery. Specifically, it is also effective against Mycoplasma pneumoniae pneumonia, trachoma caused by Chlamydia trachomatis, and Legionnaire's disease.
