Basic Information:

• Chemical Name: Calcitriol

• Other Names: Activated Vitamin D3, 1,25-Dihydroxycholecalciferol, 1,25(OH)2D3

• CAS Number: 32222-06-3

• Molecular Formula: C27H44O3

• Molecular Weight: 416.64 g/mol

Pharmacological Action:

Calcitriol is the active form of vitamin D3 and plays a crucial role in various physiological processes:

1.     Regulation of Calcium and Phosphate Homeostasis:

o    Enhances intestinal absorption of calcium and phosphate.

o    Promotes bone mineralization and maintenance of bone structure.

o    Reduces calcium excretion by the kidneys.

2.     Modulation of Immune System:

o    Influences the activity and differentiation of immune cells.

o    Exerts anti-inflammatory effects by modulating cytokine production.

3.     Gene Expression Regulation:

o    Calcitriol binds to vitamin D receptors (VDRs) in target tissues.

o    Regulates the expression of genes involved in bone metabolism, cell proliferation, differentiation, and immune response.

4.     Parathyroid Hormone (PTH) Suppression:

o    Decreases the synthesis and secretion of PTH by the parathyroid glands.

o    Used in the management of secondary hyperparathyroidism.