Chemical Information:

• Chemical Name: Tacalcitol

• Chemical Formula: C27H44O3

• Molecular Weight: 416.64 g/mol

• CAS Number: 57333-96-7

Pharmacological Actions:

Tacalcitol is a synthetic vitamin D3 analog used primarily for its effects on cellular processes involved in skin conditions.

1.     Mechanism of Action:

o    Tacalcitol binds to the vitamin D receptors (VDR) in the skin cells, particularly keratinocytes.

o    By binding to VDR, it modulates the transcription of genes that influence cellular proliferation, differentiation, and immune function.

2.     Antiproliferative Effect:

o    Tacalcitol helps to regulate the growth and differentiation of keratinocytes, thus preventing the excessive proliferation observed in conditions such as psoriasis.

3.     Immunomodulatory Effect:

o    It can modulate local immune responses, reducing inflammation and the immune-mediated damage seen in chronic skin diseases.

4.     Calcium Homeostasis:

o    Though primarily used for its dermatological benefits, tacalcitol could also influence calcium metabolism like other vitamin D analogs, but its effect on calcium and bone homeostasis is generally weak and not the primary reason for its application.