Chemical Name: Penehyclidine Hydrochloride Synonyms: Sino-1211, PHCl CAS Number: 151937-76-7
Molecular Formula: C20H30ClNO2
Molecular Weight: 351.91 g/mol
Pharmacological Effects
Penehyclidine Hydrochloride (PHCl) is a synthetic anticholinergic agent primarily used to treat peptic ulcer disease and other gastrointestinal disorders. It blocks muscarinic receptors, thereby reducing gastric acid secretion and gastrointestinal motility.
Mechanism of Action
Inhibition of Muscarinic Receptors: Penehyclidine hydrochloride selectively binds to M1 and M3 muscarinic receptors, inhibiting acetylcholine action that results in decreased secretion of gastric acids and reduced gastrointestinal motility.
Antispasmodic Effect: By blocking muscarinic receptors, penehyclidine hydrochloride decreases smooth muscle spasms, providing symptomatic relief in conditions with hyperactive gastrointestinal motility.
Bronchodilation: PHCl can also induce bronchodilation by inhibiting muscarinic receptors in the respiratory smooth muscles, although this is not its primary use.
