Molecular Formula: C15H11BrNNaO3 (anhydrous) or C15H11BrNNaO3·3/2H2O (sesquihydrate)
Molecular Weight: 356.15 (anhydrous) or 383.17 (sesquihydrate)
Physical and Chemical Properties
Melting Point: 268-270°C (dec.)
Storage Conditions: Typically requires refrigeration
Solubility: Highly soluble in DMSO and water (≥100 mg/mL)
Safety and Hazards
Warning Phrase: Danger
Hazard Statements: Specific hazard statements may include irritation or harm to skin, eyes, etc. (e.g., H372, H300, etc., but specific descriptions may vary by source)
Precautionary Statements: Provides a series of preventive measures and emergency handling guidelines (e.g., P260, P264, P270, etc.)
Uses and Efficacy
Category: Active Pharmaceutical Ingredient (API), primarily used in ophthalmic medications
Pharmacological Action: As an effective and orally active COX inhibitor, it inhibits both COX-1 and COX-2 with IC50 values of 5.56 nM and 7.45 nM, respectively. Thus, it exhibits non-steroidal anti-inflammatory/analgesic (NSAID) properties.
Clinical Applications: Commonly used for postoperative inflammation and pain management after cataract surgery, as well as in studies related to pseudophakic cystoid macular edema (CME).
