Basic Information

• Chinese Name: 己酮可可碱

• English Name: Pentoxifylline

• CAS Number: 6493-05-6

• EINECS Number: 229-374-5

• Molecular Formula: C13H18N4O3

• Molecular Weight: 278.31

Physical Properties

• Melting Point: 98-105°C

• Boiling Point: Approximately 531.3°C (at 760 mmHg), or 421.13°C (rough estimate)

• Density: 1.31 (another source states 1.1713, rough estimate)

• Refractive Index: 1.6000 (estimate)

• Solubility: Soluble in water, benzene, ethanol, and chloroform; slightly soluble in ethanol

• Odorless, with a bitter taste

Chemical Properties

• Acid Dissociation Constant (pKa): 0.50±0.70 (Predicted)

Applications and Safety

• Applications: Pentoxifylline is primarily used as a vasodilator to improve blood circulation in the brain and extremities. It is also used as an orally active, non-selective phosphodiesterase (PDE) inhibitor with immunomodulatory, anti-inflammatory, hemorheological, antifibrinolytic, and antiproliferative effects. It can be used in the study of peripheral vascular diseases, cerebrovascular diseases, etc.

• Safety Information:

• Risk Phrases (R-phrases): R22 (Harmful if swallowed)

• Safety Phrases (S-phrases): S36 (Wear suitable protective clothing)

• Storage Temperature: Store in a tightly closed container in a dry place at room temperature