Molecular Formula: C14H10N4O·HCl (or C14H11ClN4O, depending on whether it includes a water molecule)
Molecular Weight: 286.721 (or 304.736, including a water molecule)
Category: Organic raw material, pharmaceutical intermediate, biochemical and molecular biological reagent
Physical and Chemical Properties
Melting Point: >300°C
Solubility: Solubility in DMSO ≤ 4 mg/mL
Storage Conditions: 2-8°C
Uses
Olprinone Hydrochloride is a potent phosphodiesterase (PDE) 3 inhibitor with IC50 values of 150, 100, 0.35, and 14 μM for PDE1, PDE2, PDE3, and PDE4, respectively. Due to its positive inotropic and vasodilatory effects, Olprinone Hydrochloride is used in the research of heart failure. Additionally, it exhibits anti-inflammatory activity, reducing inflammatory responses associated with myocardial ischemia-reperfusion injury in animal models.
Safety Information
Hazard Symbol: Xi (Irritant)
Risk Phrases: R36/37/38 (Irritating to eyes, respiratory system, and skin)
Safety Phrases: S26 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice), S36 (Wear suitable protective clothing)
Precautionary Statements: P261 (Avoid breathing dust/fume/gas/mist/vapours/spray), P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing), etc.
