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Isosorbide Dinitrate
    Publish time 2024-09-27 15:01    

CAS NO.: 87-33-2

Isosorbide Dinitrate

Basic Information

  • Chinese Name: 硝酸异山梨酯

  • English Name: Isosorbide Dinitrate

  • CAS Number: 87-33-2

  • EINECS Number: 201-740-9

  • Molecular Formula: C6H8N2O8

  • Molecular Weight: 236.14

Physical Properties

  • Density: 1.65 g/cm³

  • Melting Point: 69°C (alternatively reported as 70°C)

  • Boiling Point: 365.9°C at 760 mmHg

  • Flash Point: 186.6°C

  • Refractive Index: 1.537

  • Vapor Pressure: 0.0±0.8 mmHg at 25°C

  • Solubility: 549.7 mg/L (25°C), freely soluble in chloroform, acetone, slightly soluble in ethanol, sparingly soluble in water

Chemical Properties

  • Odorless, with less explosive properties than nitroglycerin.

Uses

  • Isosorbide Dinitrate is a fast-acting, long-lasting nitrate anti-anginal drug with effects similar to nitroglycerin. It is primarily used for preventing angina attacks and also for symptomatic relief.

  • As a coronary vasodilator for the treatment of angina pectoris.

  • ISDN is an NO donor that prevents left ventricular remodeling and cardiac dysfunction caused by myocardial infarction (MI).

Safety Information

  • Hazard Symbol: GHS07

  • Risk Phrases: Xn

  • Signal Word: Warning

  • R-Phrases: R5; R22

  • S-Phrases: S36

  • Packing Group: II

  • UN Number for Transport of Dangerous Goods: UN 2907

Storage Conditions

  • Store in a cool, dry, and dark place in a sealed container or tank. Keep away from incompatible materials, ignition sources, and untrained individuals.