Molecular Formula: C35H38N4O6·2HCl (Note: Some sources may indicate C35H38N4O6·HCl, but considering Manidipine Dihydrochloride is the dihydrochloride salt form, C35H38N4O6·2HCl is more likely)
Molecular Weight: 683.62 (based on C35H38N4O6·2HCl)
Physical and Chemical Properties
Melting Point: 157-163°C (may vary slightly between sources)
Solubility: Soluble in DMSO (>25 mg/ml), freely soluble in water, practically insoluble in ethanol, acetone, chloroform, or ether
Stability: Stable in DMSO solution at -20°C for up to 3 months
Uses and Indications
Uses: Manidipine Dihydrochloride is a calcium channel blocker used clinically for the treatment of hypertension.
Indications: Used for hypertension, particularly suitable for patients with low renin hypertension. It is also suitable for patients with impaired renal function.
Pharmacological Effects
Manidipine Dihydrochloride blocks both L-type and T-type calcium channels, exhibiting vasodilatory effects on both afferent and efferent arterioles of the glomerulus, offering better renal protection than amlodipine.
At nanomolar concentrations, Manidipine Dihydrochloride effectively modulates gene transcription involved in pro-inflammatory changes in mesangial cells.
