Basic Information

• Chinese Name: 维格列汀

• English Name: Vildagliptin

• CAS Number: 274901-16-5

• Molecular Formula: C17H25N3O2

• Molecular Weight: 303.4    

• EINECS Number: 630-410-0

Physical and Chemical Properties

• Melting Point: 153-155°C

• Boiling Point: 531.3±50.0°C (predicted)

• Density: 1.27

• Flash Point: 275.1°C

• Solubility: Soluble in DMSO (up to 45 mg/ml), DMF (up to 20 mg/ml), or ethanol (up to 20 mg/ml)

Storage Conditions

• Should be stored in the dark, under an inert atmosphere, and in a refrigerator at -20°C or below.

Pharmacological Action

Vildagliptin is an orally administered dipeptidyl peptidase-IV (DPP-IV) inhibitor developed by Novartis Pharma AG. It was approved in the EU in 2008 for the treatment of type 2 diabetes mellitus. By inhibiting DPP-IV activity, it increases the concentrations of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), thereby promoting insulin secretion and reducing glucagon concentrations, leading to a reduction in blood glucose levels.

Clinical Applications

• In clinical studies, Vildagliptin has demonstrated good anti-diabetic effects and tolerability, both as monotherapy and in combination with metformin and insulin.