Basic Information

• Chinese Name: 盐酸索他洛尔

• English Name: Sotalol Hydrochloride

• CAS Number: 959-24-0

• Molecular Formula: C12H21ClN2O3S

• Molecular Weight: 308.82

• EINECS Number: 213-496-0

Physical and Chemical Properties

• Melting Point: 218-220°C

• Solubility: Soluble in water (20 mg/mL), readily soluble in phosphate buffer, DMSO, ethanol, and methanol

• Storage Conditions: 2-8°C, keep container tightly closed, and store in a cool, dry place

Uses and Pharmacological Effects

• Sotalol Hydrochloride is an antiarrhythmic drug with both beta-blocking and potassium channel-blocking properties.

• Clinical applications include:

• Conversion and prevention of supraventricular tachycardias, particularly atrioventricular nodal reentrant tachycardia, and also used in Wolff-Parkinson-White syndrome with supraventricular tachycardia.

• Atrial flutter and atrial fibrillation.

• Various ventricular arrhythmias, including ventricular premature beats, sustained and non-sustained ventricular tachycardia.

• Severe arrhythmias complicating acute myocardial infarction.

Safety Information

• Toxicity: LD50 (rat, oral) is 3450 mg/kg, LD50 (mouse, oral) is 2600 mg/kg, indicating moderate toxicity.

• Risk Phrases: R36/37/38, which means irritating to eyes, respiratory system, and skin.

• Safety Phrases: S26 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice) and S36 (Wear suitable protective clothing).