Solubility: Poorly soluble in water (0.1 mg/mL), slightly soluble in DMSO and methanol
Chemical Properties
Clevidipine is a novel dihydropyridine L-type voltage-dependent calcium channel blocker. Its mechanism of action involves the selective relaxation of smooth muscle in small arteries, leading to dilation of arterial blood vessels and reduction in arterial blood pressure without causing a decrease in venous blood pressure or an increase in heart rate.
Pharmacological Effects
Use: Clevidipine is primarily used for the treatment of hypertension, particularly as a short-acting intravenous dihydropyridine agent for perioperative blood pressure control and also for the management of acute hypertension. Its effects can last up to 72 hours.
Characteristics: It is rapidly metabolized to inactive products in the body, exhibiting high selectivity for vascular and myocardial tissues. It also has vasodilatory effects on systemic and pulmonary vessels.
Clinical Applications
Clevidipine was intended for short-term control of hypertension during perioperative periods and also for the treatment of acute hypertension. It can be used when oral medications are ineffective or inconvenient, with rapid onset and no accumulation in the bloodstream, making it especially suitable for patients with end-stage organ damage.
