Basic Information

• Chinese Name: 依折麦布

• English Name: Ezetimibe

• CAS Number: 163222-33-1

• Molecular Formula: C24H21F2NO3

• Molecular Weight: 409.43

Physical Properties

• Melting Point: 164-166°C

• Boiling Point: 654.9±55.0°C (Predicted)

• Density: 1.334±0.06 g/cm³ (Predicted)

Chemical Properties

Ezetimibe is a potent and selective cholesterol absorption inhibitor that works by inhibiting the absorption of cholesterol from the diet and from bile resecreted into the intestine, thereby reducing cholesterol levels in the serum and liver. It binds to the Niemann-Pick C1-Like 1 (NPC1L1) protein on the brush border membrane vesicles of the small intestine, preventing cholesterol from entering the enterocytes and, consequently, reducing the amount of cholesterol that reaches the liver.

Uses

• Pharmaceutical Raw Material: Primarily used in the pharmaceutical industry as an ingredient in cholesterol-lowering medications.

• Scientific Research: Also used in biomedical research to study cholesterol metabolism and related diseases.