Molecular Formula: C6H9NO6 (some sources may indicate C6H7NO6, which could be a typographical error or a different representation of the same core structure)
Molecular Weight: 191.14 (calculated based on C6H9NO6)
Physical and Chemical Properties
Melting Point: 88-93°C
Boiling Point: 364.5°C (at 760 mmHg)
Flash Point: 174.2°C
Density: 1.56 g/cm³
Solubility in Water: Soluble
Specific Rotation: 170º (C=1, ETOH) (mentioned in some sources)
Uses and Clinical Applications
Isosorbide 5-mononitrate is the active metabolite of isosorbide dinitrate and has the following clinical applications:
Prevention and Treatment of Angina Pectoris: After oral administration, it enters systemic circulation as the unchanged drug, bypassing hepatic metabolism, with a long duration of action and a half-life of approximately 5 hours, resulting in high bioavailability.
Long-Term Treatment of Coronary Heart Disease: Used to prevent vasospasm and mixed-type angina.
Post-Myocardial Infarction Treatment: Suitable for treatment after myocardial infarction.
Long-Term Treatment of Chronic Heart Failure: Also used in the long-term management of chronic heart failure.
Safety Instructions and Precautions
Safety Phrases: S15 (Keep away from heat sources); S16 (Keep away from sources of ignition); S37/39 (Wear suitable gloves and eye/face protection).
Risk Phrases: R11 (Highly flammable); R36/37/38 (Irritating to eyes, respiratory system, and skin).
UN Number for Transport of Dangerous Goods: UN 3251.
