Therapeutic Effects: Vortioxetine Hydrobromide is an antidepressant used primarily to treat major depressive disorder (MDD). It often improves symptoms such as mood, sleep, appetite, and energy level, and helps to restore interest in daily living.
Mechanism of Action: Vortioxetine is a multimodal antidepressant with combined properties of:
Serotonin (5-HT) reuptake inhibition.
Direct modulation of various serotonin receptors, including:
Agonism at 5-HT1A receptors.
Partial agonism at 5-HT1B receptors.
Antagonism at 5-HT3, 5-HT1D, and 5-HT7 receptors. This broad activity profile enhances serotonergic neurotransmission through several pathways, leading to an improved antidepressant effect.
