Solubility: Soluble in DMSO (slightly), methanol (slightly)
III. Chemical Properties
Acidity Coefficient (pKa): 4.01±0.10 (Predicted)
IV. Uses and Indications
Bosentan is a medication used to treat pulmonary arterial hypertension (PAH). It is a non-selective endothelin receptor antagonist that reverses the vasoconstrictive, proliferative, and profibrotic effects of endothelin-1, as well as influencing other growth factors and modulating ion channels in vascular smooth muscle cells. Oral bosentan is considered a first-line therapy for PAH, indicated for the treatment of World Health Organization (WHO) functional class III and IV idiopathic PAH or PAH associated with scleroderma.
V. Storage and Transportation
Bosentan should typically be stored at -20°C in a freezer to ensure stability and efficacy. During transportation, exposure to high temperatures and humidity should be avoided to maintain product quality.
