Molecular Formula: C56H70N9NaO23S (may vary slightly by source, e.g., C56H72N9NaO23S)
Molecular Weight: Approximately 1292.26 to 1294.28 (depending on source)
Physical Properties
Appearance: White to off-white solid
Melting Point: >180°C (decomposes)
Solubility: Soluble in DMSO (slightly), methanol (slightly), and water (with sonication). Approximate solubility in water at 25°C is 100 mg/mL, and in DMSO is 30 mg/mL.
Chemical Properties
Stability: Has hygroscopic properties, should be stored in a light-protected, dry, and sealed container. Recommended storage temperature is below -20°C.
Mechanism of Action: Micafungin Sodium is a semisynthetic echinocandin lipopeptide that acts as a non-competitive inhibitor of 1,3-β-D-glucan synthase. It disrupts the fungal cell wall by inhibiting the synthesis of 1,3-β-D-glucan, leading to cell death.
Pharmacological Effects
Indications: Used primarily for the treatment of invasive candidiasis, esophageal candidiasis, and prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation. Also effective against certain invasive aspergillosis infections.
Drug Interactions: As Micafungin Sodium is not metabolized by cytochrome P450 enzymes and is not a substrate for P-glycoprotein in the intestine or tissues, it has fewer drug interactions. However, monitoring of blood levels and dose adjustments may be necessary when used concomitantly with certain drugs (e.g., cyclosporine, sirolimus, nifedipine).
