Chemical Name: Sitafloxacin CAS Number: 127254-12-0 Molecular Formula: C19H18FN3O3 Molecular Weight: 355.37 g/mol
Pharmacological Effects
Antibacterial Spectrum: Sitafloxacin is a fluoroquinolone antibiotic that exhibits a broad spectrum of antibacterial activity. It is effective against both Gram-positive and Gram-negative bacteria, including strains resistant to other antibiotics.
Mechanism of Action:
- Inhibition of DNA Gyrase and Topoisomerase IV: Sitafloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes that are crucial for DNA replication, transcription, repair, and recombination. This inhibition leads to the disruption of bacterial DNA processes, resulting in bacterial cell death.
Cross-resistance: Despite being a fluoroquinolone, Sitafloxacin has shown effectiveness against bacteria that are resistant to other fluoroquinolones, making it valuable in treating multi-drug resistant infections.
