Molecular Weight: 763.1 g/mol (including the fumarate part)
Pharmacological Actions
Bedaquiline Fumarate is used primarily as an anti-tuberculosis agent for the treatment of multi-drug resistant tuberculosis (MDR-TB). The drug exhibits its pharmacological effects through the following mechanisms:
Inhibition of ATP Synthase: Bedaquiline targets the mycobacterial ATP synthase enzyme, which is essential for the generation of ATP. The inhibition of this enzyme disrupts the production of energy within bacterial cells, leading to cellular death.
Bactericidal Action: By specifically affecting mycobacterial ATP synthesis, the drug exerts a bactericidal effect, effectively killing the tuberculosis bacteria.
