Mizolastine is a specific and selective peripheral histamine H1 receptor antagonist with antihistaminic and anti-allergic properties. Below is a detailed introduction to Mizolastine (mizolastine):
Basic Information
English Name: Mizolastine
CAS Number: 108612-45-9
Molecular Formula: C24H25FN6O
Molecular Weight: 432.5
Pharmacological Action
Mizolastine exhibits a high degree of specificity for the H1 receptor, but has no effect on 5-HT, norepinephrine, or muscarinic acetylcholine receptors. Its anti-allergic effects extend beyond merely blocking the H1 receptor and include the following mechanisms:
Inhibition of allergen-induced histamine release and suppression of histamine-mediated allergic inflammation, such as increased capillary permeability, vascular exudation, tissue edema, and bronchospasm.
Inhibition of arachidonic acid-induced tissue edema and suppression of 5-lipoxygenase activity, thereby inhibiting the production of leukotrienes in the body.
Inhibition of CD63 expression on the surface of basophils.
Inhibition of ICAM-1 (intercellular adhesion molecule-1) release.
Indications
Mizolastine is primarily used in the treatment of seasonal and perennial allergic rhinitis, allergic conjunctivitis, urticaria, and other allergic symptoms.
