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Cefixime
    Publish time 2024-09-25 10:12    

CAS No.: 79350-37-1


Cefixime

Basic Information

  • Product name: Cefixime

  • Chemical Formula: C16H15N5O7S2

  • Molecular Weight: 453.450 g/mol

  • CAS Number: 79350-37-1

Physical and Chemical Properties

  • Appearance: White to off-white crystalline powder

  • Density: 1.85 g/cm³ (also reported as 1.9±0.1 g/cm³)

  • Melting Point: 218 to 225 °C

  • Solubility: Practically insoluble in water, soluble in ethanol or dimethyl sulfoxide, slightly soluble in acetone, practically insoluble in hexane, ethyl acetate

  • Molar Refractivity: 130.08

  • Molar Volume (cm³/mol): 302.7

  • Isotropic Birefringence: 51.57

  • Surface Tension (dyne/cm): 77.7

  • Polarizability (10^-24cm³): 51.57

Pharmaceutical Information

  • Indications: Used for the treatment of infections caused by susceptible bacteria in respiratory, urinary, and biliary tracts, such as bronchitis, pneumonia, pyelonephritis, cystitis, urethritis, cholecystitis, cholangitis, otitis media, sinusitis, scarlet fever, etc.

  • Route of Administration: Oral

  • Adverse Reactions: Most are transient and mild, including allergic reactions (e.g., rash, urticaria), gastrointestinal reactions (e.g., diarrhea, stomach discomfort), respiratory reactions (e.g., interstitial pneumonia), hematological reactions (e.g., eosinophilia), and liver and kidney impairment.

  • Precautions: Safety and effectiveness in pregnant and lactating women, and children under 6 months of age have not been established. Weigh the risks and benefits before use. Patients with a history of penicillin allergy, renal impairment, etc., should use with caution.