Azelastine Hydrochloride is a safe and effective antihistamine medication widely used in the treatment of allergic rhinitis, asthma, and other allergic conditions.
Basic Information
English Name: Azelastine Hydrochloride
CAS No.:: Azelastine, 79307-93-0
Molecular Formula: C22H25Cl2N3O
Molecular Weight: 418.36
Pharmacological Mechanism
H1 Receptor Antagonism: Azelastine competitively and selectively binds to H1 receptors, blocking the actions of histamine, a key mediator of allergic reactions.
Mast Cell Stabilization: It enhances the stability of mast cell membranes, inhibiting the release of histamine, leukotrienes, and other inflammatory mediators.
Antagonism of Other Inflammatory Mediators: Azelastine significantly inhibits the actions of bradykinin, substance P, serotonin, and platelet-activating factor.
Suppression of Airway Inflammatory Cells: It significantly reduces eosinophil infiltration in animal models of asthma.
β2-Adrenergic Receptor Sensitization: Enhances the sensitivity of β2-adrenergic receptors in the airways, reversing downregulation caused by chronic β2-agonist use.
Indications
Primarily used in the treatment of allergic rhinitis, asthma, and other allergic conditions.
Some research has explored its potential applications in diabetes, hyperlipidemia, and against SARS-CoV-2.
