Allopurinol is an organic compound primarily used as an anti-gout medication.
Basic Information
Chemical Name: 1H-Pyrazolo[3,4-d]pyrimidin-4-ol
Chemical Formula: C5H4N4O
Molecular Weight: 136.11
CAS Registry Number: 315-30-0
Pharmacological Action
Allopurinol is an isomer of hypoxanthine and functions as an inhibitor of xanthine oxidase (XO). It competitively inhibits the activity of xanthine oxidase, thereby reducing uric acid production, ultimately treating gout. Additionally, Allopurinol possesses antioxidant properties by decreasing the generation of oxygen free radicals during ischemia-reperfusion injury.
Indications
Primary and secondary hyperuricemia: Especially in cases where hyperuricemia is caused by excess uric acid production.
Recurrent or chronic gout: Suitable for patients with recurrent or chronic gout attacks.
Tophi: Aids in the redissolution of tophi and uric acid crystals.
Uric acid nephrolithiasis and/or uric acid nephropathy: Reduces the deposition of urate salts in bones, joints, and the kidneys.
Hyperuricemia in renal insufficiency: Can be used in patients with renal insufficiency who have hyperuricemia.
