Mechanism of Action: Ofloxacin primarily works by inhibiting the activity of bacterial DNA gyrase and topoisomerase IV, enzymes critical for the replication and transcription processes of bacterial DNA. This inhibition ultimately leads to bacterial cell death. Consequently, it exerts bacteriostatic and bactericidal effects against a wide range of Gram-positive and Gram-negative bacteria.
Antibacterial Spectrum: - Gram-negative bacteria: Such as Escherichia coli, Klebsiella species, Pseudomonas aeruginosa, and Neisseria gonorrhoeae. - Gram-positive bacteria: Such as Staphylococcus aureus and Streptococcus species. - Atypical pathogens: Including Chlamydia, Mycoplasma, and certain Mycobacterium species.
