Celecoxib, also known as Celebrex, is a nonsteroidal anti-inflammatory drug (NSAID) that specifically inhibits cyclooxygenase-2 (COX-2). By blocking the activity of COX-2, it disrupts the synthesis of prostaglandins from arachidonic acid, thereby exerting its anti-inflammatory and analgesic effects.
Basic Information
English Name: Celecoxib
Chemical Formula: C17H14F3N3O2S
Molecular Weight: 381.37
CAS Registry Number: 169590-42-5
Pharmacological Action
Celecoxib selectively inhibits COX-2, reducing the synthesis of prostaglandin E2 and F2α, thus providing analgesia and anti-inflammatory actions. This selectivity helps minimize gastrointestinal side effects, although risks still exist.
Clinical Applications
Celecoxib is primarily used to treat various types of pain and inflammation, including:
