Parecoxib Sodium is a non-steroidal anti-inflammatory drug (NSAID) that has garnered significant attention in research and clinical settings due to its high selectivity and potent oral activity.
Basic Information
English Name: Parecoxib Sodium
CAS Number: 198470-85-8
Molecular Formula: C19H17N2NaO4S
Molecular Weight: 392.4
Pharmacological Action
Parecoxib Sodium exerts its pharmacological effects primarily by inhibiting the activity of cyclooxygenase-2 (COX-2), thereby suppressing the synthesis of prostaglandins. As a prodrug of Valdecoxib, it demonstrates potent inhibition of COX-2 in vitro and can inhibit cell proliferation and migration in a dose-dependent manner.
Clinical Applications
While Parecoxib Sodium is primarily used in research experiments, its clinical applications are also being explored. Several clinical trials have assessed its use in postoperative pain management, pain threshold modulation, shoulder pain, and laparoscopic surgery. For instance, studies have shown that Parecoxib Sodium is comparable to ketorolac and morphine in alleviating postoperative pain, with fewer side effects.
