Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist.
Basic Information
English Name: Cetrorelix Acetate
CAS Number: 130143-01-0
Molecular Formula: C74H100ClN17O18
Molecular Weight: 1551.16
Pharmacological Action
Cetrorelix Acetate serves as a potent antagonist of the GnRH receptor, blocking the binding of GnRH to its receptor and thereby inhibiting the secretion of gonadotropins (e.g., luteinizing hormone and follicle-stimulating hormone). This mechanism of action renders Cetrorelix Acetate useful in various clinical applications, particularly in assisted reproductive technology and the treatment of hormone-related disorders.
Clinical Applications
Assisted Reproductive Technology (ART): In ART procedures such as in vitro fertilization (IVF), Cetrorelix Acetate is used to control ovarian stimulation, preventing premature ovulation of immature follicles, and thereby enhancing the chances of conception. It is often administered in conjunction with gonadotropins (e.g., urinary-derived or recombinant gonadotropins) to optimize the ovarian stimulation process.
Treatment of Hormone-Related Disorders: Extensive research has shown that Cetrorelix Acetate exhibits favorable therapeutic effects in ovarian cancer, prostate cancer, uterine fibroids, endometriosis, and other conditions. Furthermore, it is used to prevent and mitigate benign prostatic hypertrophy and ovarian hyperstimulation syndrome.
