Triptorelin Acetate, also known as triptorelin, is a synthetic gonadotropin-releasing hormone (GnRH) analogue primarily used in the treatment of various hormone-related diseases.
I. Basic Information
English Name: Triptorelin Acetate
CAS Number: 140194-24-7
Molecular Formula: C64H82N18O13·C2H4O2
Molecular Weight: Approximately 1371.52
II. Pharmacological Action
As a GnRH analogue, Triptorelin Acetate exerts its pharmacological effects primarily through the regulation of gonadotropin (Gn) secretion. Initial injections stimulate the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), i.e., gonadotropins (Gn). However, prolonged stimulation leads to a refractory period in the pituitary gland, resulting in decreased Gn release and subsequently lowering sex steroid (such as testosterone or estrogen) levels to castration levels. This effect is reversible.
III. Indications
Prostate Cancer: Primarily used in the treatment of hormone-dependent prostate cancer.
Endometriosis: By inhibiting the secretion of estradiol, it puts ectopic endometrial tissue into a resting state.
Uterine Fibroids: During treatment, uterine fibroids may shrink.
Precocious Puberty: Suppresses the hypersecretion of pituitary gonadotropins, thereby inhibiting the secretion of sex hormones.
Assisted Reproductive Technology (ART): Used in conjunction with gonadotropins (such as hMG, FSH, hCG) in in vitro fertilization-embryo transfer procedures to promote ovulation.
