Dydrogesterone, also known as the generic name for a type of oral progestogen medication, is primarily used to treat various conditions caused by inadequate endogenous progesterone levels. Below is a detailed introduction to Dydrogesterone:
I. Basic Information
Chemical Name: 9β,10α-Pregnane-4,6-diene-3,20-dione
English Name: Dydrogesterone
Molecular Formula: C21H28O2
Molecular Weight: 312.45
II. Indications
Dydrogesterone is used to treat the following conditions caused by insufficient endogenous progesterone:
Dysmenorrhea (Painful Menstruation)
Endometriosis
Secondary Amenorrhea
Irregular Menstrual Cycle
Dysfunctional Uterine Bleeding
Premenstrual Syndrome (PMS)
Threatened or Habitual Abortion Due to Progesterone Deficiency
Infertility Caused by Inadequate Corpus Luteum Function
III. Pharmacological Action
Dydrogesterone is an oral progestogen that brings the endometrium into a full secretory phase, thereby preventing endometrial hyperplasia and reducing the risk of cancer caused by estrogen. Dydrogesterone is completely metabolized in the body, with the primary metabolite being DHD (20a-dihydrogesterone), which is mostly excreted in the urine as a glucuronide conjugate. The structure of all metabolites retains the 4,6-diene-3-one configuration, preventing estrogenic and androgenic effects.
