Bimatoprost is a prostaglandin analog primarily used in ophthalmology, particularly for the management of glaucoma and intraocular pressure (IOP) elevation.
I. Basic Information
English Name: Bimatoprost
Molecular Formula: C25H37NO4
Molecular Weight: 415.57
CAS Registry Number: 155206-00-1
II. Pharmacological Action
Bimatoprost reduces intraocular pressure (IOP) by increasing the outflow of aqueous humor from the eye, by approximately 13% during the day and 14% at night.
It primarily acts on prostaglandin receptors, particularly the FP receptor, activating the pressure-sensitive outflow pathway, which subsequently reduces IOP.
III. Clinical Applications
Glaucoma Treatment: Bimatoprost serves as a valuable medication for treating glaucoma by significantly decreasing IOP and preventing disease progression.
IOP Elevation Management: It is also effective in managing other ocular conditions associated with elevated IOP.
Eyelash Growth: Notably, in 2008, the United States Food and Drug Administration (FDA) approved Bimatoprost for the cosmetic use of eyelash growth under the brand name Latisse.
