Medroxyprogesterone Acetate, also known as MPA, is a progestin medication widely used in medical practice.
I. Basic Information
English Name: Medroxyprogesterone Acetate
Molecular Formula: C24H34O4
Molecular Weight: 386.52
CAS Registry Number: 71-58-9
Chemical Name: 6α-Methyl-17α-hydroxypregna-4-ene-3,20-dione acetate
II. Pharmacological Action
MPA belongs to the class of progestogens, primarily acting on the endometrium to promote its proliferation and secretion.
It exerts its effect by inhibiting the release of luteinizing hormone from the anterior pituitary gland through negative feedback on the hypothalamus, thereby suppressing ovarian ovulation.
Its anticancer properties may be related to its anti-estrogenic effects.
III. Clinical Applications
MPA tablets (e.g., Medroxyprogesterone Acetate Tablets) are commonly used to treat menstrual disorders, functional uterine bleeding, endometriosis, and other gynecological conditions.
Following high-risk abortions, MPA tablets may be prescribed to promote endometrial repair and restore normal menstrual cycles.
The depot form of MPA (Depo-Provera) is a long-acting injectable contraceptive that prevents pregnancy by inhibiting ovulation.
